PDRN — what it does & which products use it

PDRN

INCI: Polydeoxyribonucleotide (often listed as Salmon DNA / Sodium DNA)

PDRN stands for polydeoxyribonucleotide — short fragments of DNA, most often derived from salmon, used in skincare as a hydrating, soothing and barrier-supporting active. In topical formulas it is generally positioned as a "skin-conditioning" ingredient aimed at comfort, plumpness and a smoother look.

Helps with

Dehydration, Redness, Fine lines, Texture, post-procedure-comfort

Suits

Dry, Sensitive, Normal / balanced, Combination, Oily

Use with care

Well tolerated by most people, including sensitive skin. Avoid if you have a fish or salmon allergy, as many versions are salmon-derived. Not a substitute for prescribed treatment, and injectable PDRN is a clinical procedure that should only be discussed with a qualified practitioner.

Evidence
Most published research on PDRN comes from injectable or clinical settings rather than over-the-counter creams and serums, so topical results are likely to be gentler and more gradual. Early studies suggest it may help skin feel more hydrated and less reactive. Cosmetic claims should be read as appearance-related, not medical.

Shop